Depression & Osteoporosis - A Study

October 31, 2006

Feeling down? Depression may cause bone loss. Scientists say antidepressants could offer treatment for osteoporosis

“The new findings ... point for the first time to depression as an important element in causing bone mass loss and osteoporosis,” Hebrew University professor Raz Yirmiya, who took part in the study, said in a statement.

JERUSALEM - Depression can lead to brittle bones, Israeli scientists found in a new study released on Monday that also suggested antidepressant drugs could be used to treat osteoporosis.

The scientists, at Jerusalem’s Hebrew University, said mice that were given drugs to induce behavior similar to human depression suffered from a loss of mass in their bones, mainly their hips and vertebrae.

After being given antidepressants, the bone density of the mice increased, along with their level of activity and social interaction, the scientists said.

Depression activates the “sympathetic nervous system”, which responds to impending danger or stress, causing the release of a chemical compound called noradrenaline that harms bone-building cells, the study showed.

Antidepressant drugs block noradrenaline and reverse its negative effects, according to the findings, which will be published this week in the American journal PNAS (Proceedings of the National Academy of Sciences).

A study published earlier this month by the Forsyth Institute in Boston found that fluoxetine, used in the popular anti-depressant drug Prozac, also increased bone mass in mice.

Osteoporosis weakens bones and makes them more likely to fracture. It is treatable but affects millions and is most prevalent among postmenopausal women.

Copyright 2006 Reuters Limited